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Protein Name: vif Gene: vif Source: HIV1 Acc. No.: PR.W54643029
PDB ID: 3DCG
SwissProt ID: sp|P31820.1|
RefSeq ID: |ref|NP_057851.1|
Motifs: PS00005, PS00008, PS00004, PS00006,
Function(s): -Its role is to disrupt the antiviral activity of the human enzyme APOBEC (See also APOBEC3G) by targeting it for ubiquitination and cellular degradation. APOBEC is a cytidine deaminase enzyme that mutates viral nucleic acids.
Description: Vif is a 23-kilodalton protein that is essential for viral replication. Vif inhibits the cellular protein, APOBEC3G, from entering the virion during budding from a host cell by targeting it for proteasomal degradation.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Vif Gene: vif Source: HIV2 Acc. No.: PR.W47965707
PDB ID: NA
SwissProt ID: sp|P18097.1|VIF_HV2BE
RefSeq ID: ref|NP_056839.1|
Motifs: PS00005, PS00006, PS00008, PS00007, PS00004,
Function(s): -Counteracts the innate antiviral activity of APOBEC3G. Forms a complex with host APOBEC3G thus preventing the entry of this lethally hypermutating enzyme into progeny virions. Functions as an adapter molecule, recruiting APOBEC3G to the ubiquitin-proteasome machinery. Targets APOBEC3G for degradation through the assembly with elongin BC complex, CUL5 and RBX1. Binds viral RNA and affects the stability of viral nucleoprotein core. May play a role in viral morphology.
Description: Virion infectivity factor (VIF) is one of the HIV accessory proteins and is conserved in the primate lentivirus groups. In the absence of vif gene, HIV-1 and HIV-2 infection of non-permissive cells, like PBMCs(Peripheral blood mononuclear cell), produce no virion. This protein is, therefore, a new potential target for retroviral strategy.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Vif Gene: vif Source: SIV Acc. No.: PR.Z71099277
PDB ID: NA
SwissProt ID: sp|Q02841.1|VIF_SIVG1
RefSeq ID: ref|NP_054370.1|
Motifs: PS00005, PS00006, PS00008, PS00004,
Function(s): -Counteracts the innate antiviral activity of APOBEC3G. Forms a complex with host APOBEC3G thus preventing the entry of this lethally hypermutating enzyme into progeny virions. Functions as an adapter molecule, recruiting APOBEC3G to the ubiquitin-proteasome machinery. Targets APOBEC3G for degradation through the assembly with elongin BC complex, CUL5 and RBX1. Binds viral RNA and affects the stability of viral nucleoprotein core. May play a role in viral morphology.
Description: Counteracts the innate antiviral activity of APOBEC3G. Forms a complex with host APOBEC3G thus preventing the entry of this lethally hypermutating enzyme into progeny virions. Functions as an adapter molecule, recruiting APOBEC3G to the ubiquitin-proteasome machinery. Targets APOBEC3G for degradation through the assembly with elongin BC complex, CUL5 and RBX1. Binds viral RNA and affects the stability of viral nucleoprotein core. May play a role in viral morphology.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References