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Protein Name: Tat Gene: tat Source: HIV1 Acc. No.: PR.F21473189
PDB ID: 1NBK
SwissProt ID: sp|P04608.2|TAT_HV1H2
RefSeq ID: |ref|NP_057853.1|
Motifs: PS50311, PS00008, PS00009, PS00016,
Function(s): -Tat binds to cellular factors and mediates their phosphorylation, resulting in increased transcription of all HIV genes, providing a positive feedback cycle.
Description: Tat is a HIV gene.Tat stands for ""Trans-Activator of Transcription"". Tat consists of between 86 and 101 amino acids depending on the subtype. Tat contains a protein transfer domain. This domain allows Tat to enter cells by crossing the cell membrane. The biological role of this domain and exact mechanism of transfer is unknown.Tat vastly increases the level of transcription of the HIV dsRNA.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Tat Gene: tat Source: HIV2 Acc. No.: PR.B65931369
PDB ID: NA
SwissProt ID: sp|P18098.1|TAT_HV2BE
RefSeq ID: ref|NP_056842.1|
Motifs: PS50079, PS00005, PS00006, PS00008, PS00009, PS00004,
Function(s): - Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts.
- Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors. Endosomal low pH allows Tat to cross the endosome membrane to enter the cytosol and eventually further translocate into the nucleus, thereby inducing severe cell dysfunctions ranging from cell activation to cell death.
Description: * Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts. * Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors. Endosomal low pH allows Tat to cross the endosome membrane to enter the cytosol and eventually further translocate into the nucleus, thereby inducing severe cell dysfunctions ranging from cell activation to cell death.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References