Home | University of Hyderabad | UOHBIF

 Search result for  'rev'
Save data in tab delimited text file

Protein Name: Rev Gene: rev Source: HIV1 Acc. No.: PR.C22896603
PDB ID: 2X7L
SwissProt ID: sp|P04618.1|REVHV1H2
RefSeq ID: ref|NP_057854.1
Motifs: PS00006, PS00005, PS00008,
Function(s): - Binds to RRE(Rev responsive Element), which facilitates export of unspliced and incompletely spliced viral RNA from nucleus to cytoplasm.
- upregulates expression of structural genes (gag, pol, env)
- downregulates expression of regulatory genes (rev, tat)
- sequence-specific RNA-binding protein.
- transports genomic transcripts from nucleus to cytoplasm
- induces the transition from early to late phase of HIV gene expression
Description: HIV-1 Rev is a small regulatory protein that mediates the nuclear export of viral mRNAs, an essential step in the HIV replication cycThe Rev protein (p19) is involved in shuttling RNAs from the nucleus and the cytoplasm by binding to the RRE RNA element.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: p51 reverse transcriptase Gene: pol Source: HIV1 Acc. No.: PR.K54707344
PDB ID: 3K2P
SwissProt ID: sp|P03366.3|POL_HV1B
RefSeq ID: |ref|NP_789739.1
Motifs: PS00005,
Function(s): - RT makes a double-stranded DNA copy of the dimer of single-stranded RNA
- RT has both RNA-dependant and DNA-dependant polymerase activity
Description: Reverse transcriptase, also known as RNA-dependent DNA polymerase, is a DNA polymerase enzyme that transcribes single-stranded RNA into double-stranded DNA. It also helps in the formation of a double helix DNA once the RNA has been reverse transcribed into a single strand cDNA.HIV-1 RT is from the human immunodeficiency virus and is a heterodimer of P66 and P51.This hand-like heterodimer protein that has an usual length of 1000 residues (560 in Chain A and 440 for B), the third of them involved in alpha helical and almost a quarter in beta sheets,showing α+β secondary structure domains; Chain A has an usual weight of 66KDa whereas Chain B is around 51KDa, those monomers are derived from the same gen but p51 lacks the amino acids of one active site and has a different tertiary structure conformation compared with p66, for this reason is totally inactive.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
Drugs

References


Protein Name: Rev Gene: rev Source: HIV2 Acc. No.: PR.G33127389
PDB ID: NA
SwissProt ID: sp|P18093.1|REV_HV2BE
RefSeq ID: ref|NP_056843.1|
Motifs: PS50323, PS00005, PS00006,
Function(s): -Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs
Description: Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..