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Protein Name: protease Gene: pol Source: HIV1 Acc. No.: PR.B36944284
PDB ID: 1KZK
SwissProt ID: sp|p04591.3|GAGHV1H2
RefSeq ID: ref|NP_057850.1|
Motifs: PS50175, PS00141, PS00005, PS00008, PS00006,
Function(s): -cleave the nascent polyproteins during viral replication
Description: A protease is an enzyme that cleaves proteins to their component peptides. The HIV-1 Protease (PR) hydrolyzes viral polyproteins into functional protein products that are essential for viral assembly and subsequent activity. This maturation process occurs as the virion buds from the host cell.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
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Protein Name: p51 reverse transcriptase Gene: pol Source: HIV1 Acc. No.: PR.K54707344
PDB ID: 3K2P
SwissProt ID: sp|P03366.3|POL_HV1B
RefSeq ID: |ref|NP_789739.1
Motifs: PS00005,
Function(s): - RT makes a double-stranded DNA copy of the dimer of single-stranded RNA
- RT has both RNA-dependant and DNA-dependant polymerase activity
Description: Reverse transcriptase, also known as RNA-dependent DNA polymerase, is a DNA polymerase enzyme that transcribes single-stranded RNA into double-stranded DNA. It also helps in the formation of a double helix DNA once the RNA has been reverse transcribed into a single strand cDNA.HIV-1 RT is from the human immunodeficiency virus and is a heterodimer of P66 and P51.This hand-like heterodimer protein that has an usual length of 1000 residues (560 in Chain A and 440 for B), the third of them involved in alpha helical and almost a quarter in beta sheets,showing α+β secondary structure domains; Chain A has an usual weight of 66KDa whereas Chain B is around 51KDa, those monomers are derived from the same gen but p51 lacks the amino acids of one active site and has a different tertiary structure conformation compared with p66, for this reason is totally inactive.
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Protein Name: p15 RNase H Gene: pol Source: HIV1 Acc. No.: PR.P60354771
PDB ID: 3LP3
SwissProt ID: sp|P04585|HIV-1 HXB2 POL|
RefSeq ID: ref|NP_057854.1
Motifs: NA,
Function(s): -Removes RNA template strand from RNA/DNA duplex.
Description: The enzyme RNase H is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.RNase exists in both free enzyme form and as a domain in the HIV-1 reverse transcriptase enzyme.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
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Protein Name: Integrase Gene: pol Source: HIV1 Acc. No.: PR.O67715130
PDB ID: 1BIS
SwissProt ID: sp|P04585.4|POL_HV1H2
RefSeq ID: ref|YP_001856243.1|
Motifs: PS50876, PS50994, PS51027, PS00008, PS00007, PS00006, PS00001, PS00005,
Function(s): - Catalyzes viral DNA integration into the host chromosome
- exonuclease activity trims two nucleotides from each 3 -end of the linear DNA duplux
- double-stranded endonuclease activity cleaves the host DNA at the integration site
- ligase activity generates a single covalent linkage at each end of viral DNA
Description: Human immunodeficiency virus type 1 (HIV-1), like all retroviruses, depends upon the integration of a DNA copy of its viral genome into host cell chromosomes as part of its infection cycle. Multiple steps in this integration process are catalyzed by HIV-1 integrase.The full length HIV-1 integrase (288 amino acids) has three domains; the catalytic core, the C-terminal, and the N-terminal domains.
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Protein Name: pol polyprotein Gene: pol Source: HIV1 Acc. No.: PR.M22624172
PDB ID: NA
SwissProt ID: sp|P04585|HIV-1 HXB2 Pol|
RefSeq ID: ref|NP_057849.4|
Motifs: PS50175, PS50878, PS50879, PS50876, PS50994, PS51027, PS00141, PS00005, PS00008, PS00006, PS00007, PS00004, PS00001,
Function(s): -
- precursor for viral enzymes
- during viral maturation, viral protease cleaves the Pol polyprotein away from Gag, and further digests it to separate it into 4 proteins: protease, reverse transcriptase, RNase H, and Integrase
Description: Pol genes are found in many retroviruses, including a number that are harbored by human populations. All of the polgene products can be found in the capsid of the virion. The GAG gene provides the basic physicalinfrastructure ofthe virus, and POL provides the basic mechanism by which retroviruses reproduce, while the others help HIV to enter the host cell and enhance its reproduction .
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
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Protein Name: Gag-Pol Gene: pol Source: SIV Acc. No.: PR.O99917932
PDB ID: NA
SwissProt ID: sp|Q02836.2|POL_SIVG1
RefSeq ID: ref|NP_687035.1|
Motifs: PS50175, PS50878, PS50879, PS50876, PS50158, PS51027, PS00141, PS00009, PS00005, PS00008, PS00006, PS00007, PS00004, PS00001,
Function(s): -Gag-Pol polyprotein and Gag polyprotein may regulate their own translation, by the binding genomic RNA in the 5 -UTR. At low concentration, Gag-Pol and Gag would promote translation, whereas at high concentration, the polyproteins encapsidate genomic RNA and then shutt off translation.
Description: Gag-Pol polyprotein and Gag polyprotein may regulate their own translation, by the binding genomic RNA in the 5 -UTR. At low concentration, Gag-Pol and Gag would promote translation, whereas at high concentration, the polyproteins encapsidate genomic RNA and then shutt off translation.
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References


Protein Name: Pol Gene: pol Source: FIV Acc. No.: PR.U44552444
PDB ID: 1F7D
SwissProt ID: sp|P16088.1|POL_FIVPE
RefSeq ID: ref|NP_040973.1|
Motifs: PS50878, PS50879, PS50876, PS50994, PS51027, PS00016, PS00005, PS00008, PS00006, PS00007, PS00004, PS00001, PS00009,
Function(s): -During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
Description: During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Pol Gene: pol Source: EIAV Acc. No.: PR.T66742577
PDB ID: NA
SwissProt ID: sp|P32542.1|POL_EIAVC
RefSeq ID: ref|NP_056902.1|
Motifs: PS50175, PS50878, PS50879, PS50876, PS51027, PS00141, PS50994, PS00009, PS00005, PS00008, PS00006, PS00007, PS00004, PS00001, PS00016,
Function(s): -During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
Description: During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References