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Protein Name: env Gene: env Source: HIV2 Acc. No.: PR.P35434412
PDB ID: NA
SwissProt ID: sp|P18094|ENV_HV2BE
RefSeq ID: ref|NP_056844.1|
Motifs: PS00006, PS00008, PS00005, PS00001, PS00007, PS00004,
Function(s): -The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.
Description: The genomes of HIV1 and HIV2 are similar there are significant differences in nucleotide and amino acid sequences, most marked with the envelope genes and proteins. Both viruses, however, bind to the same CD4 cellular receptor. HIV2 is largely confined to West Africa where it is the dominant HIV, though patients infected with HIV2 have been described in Europe and America. Its transmission, clinical features and immunological effects are similar to those associated with HIV1 infection.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Gag Gene: gag Source: HIV2 Acc. No.: PR.D50692448
PDB ID: 2WLV
SwissProt ID: sp|P18095.3|GAG_HV2BE
RefSeq ID: ref|NP_056837.1|
Motifs: PS50158, PS00008, PS00006, PS00009, PS00001, PS00005, PS00007,
Function(s): - Matrix protein p17 targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal. Also mediates nuclear localization of the preintegration complex.
- Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.
- Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers.
- p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
Description: * Matrix protein p17 targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal. Also mediates nuclear localization of the preintegration complex. * Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. * Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. * p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
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References


Protein Name: Nef Gene: nef Source: HIV2 Acc. No.: PR.C91897139
PDB ID: 3IK5
SwissProt ID: sp|P18092.3|NEF_HV2BE
RefSeq ID: ref|NP_056845.1|
Motifs: PS00006, PS00008, PS00005, PS00001, PS00016, PS00004,
Function(s): -Nef has been shown to be a major determinant of virus pathogenicity,in vivo.But in invitro, many different Nef activities have been reported, including CD4 and MHC I downregulation, enhanced virion infectivity, and T-cell activation.
Description: Nef is a 27 kD myristoylated protein encoded at the 3' ends of the HIV-1, HIV-2, and SIV genomes. It has been shown to play a critical role in the pathogenesis of AIDS in monkeys and therefore is likely to be important for the development of HIV disease in humans.
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References


Protein Name: Rev Gene: rev Source: HIV2 Acc. No.: PR.G33127389
PDB ID: NA
SwissProt ID: sp|P18093.1|REV_HV2BE
RefSeq ID: ref|NP_056843.1|
Motifs: PS50323, PS00005, PS00006,
Function(s): -Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs
Description: Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..

Protein Name: Tat Gene: tat Source: HIV2 Acc. No.: PR.B65931369
PDB ID: NA
SwissProt ID: sp|P18098.1|TAT_HV2BE
RefSeq ID: ref|NP_056842.1|
Motifs: PS50079, PS00005, PS00006, PS00008, PS00009, PS00004,
Function(s): - Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts.
- Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors. Endosomal low pH allows Tat to cross the endosome membrane to enter the cytosol and eventually further translocate into the nucleus, thereby inducing severe cell dysfunctions ranging from cell activation to cell death.
Description: * Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts. * Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors. Endosomal low pH allows Tat to cross the endosome membrane to enter the cytosol and eventually further translocate into the nucleus, thereby inducing severe cell dysfunctions ranging from cell activation to cell death.
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References


Protein Name: Vif Gene: vif Source: HIV2 Acc. No.: PR.W47965707
PDB ID: NA
SwissProt ID: sp|P18097.1|VIF_HV2BE
RefSeq ID: ref|NP_056839.1|
Motifs: PS00005, PS00006, PS00008, PS00007, PS00004,
Function(s): -Counteracts the innate antiviral activity of APOBEC3G. Forms a complex with host APOBEC3G thus preventing the entry of this lethally hypermutating enzyme into progeny virions. Functions as an adapter molecule, recruiting APOBEC3G to the ubiquitin-proteasome machinery. Targets APOBEC3G for degradation through the assembly with elongin BC complex, CUL5 and RBX1. Binds viral RNA and affects the stability of viral nucleoprotein core. May play a role in viral morphology.
Description: Virion infectivity factor (VIF) is one of the HIV accessory proteins and is conserved in the primate lentivirus groups. In the absence of vif gene, HIV-1 and HIV-2 infection of non-permissive cells, like PBMCs(Peripheral blood mononuclear cell), produce no virion. This protein is, therefore, a new potential target for retroviral strategy.
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References


Protein Name: Vpr Gene: vpr Source: HIV2 Acc. No.: PR.Z87416323
PDB ID: NA
SwissProt ID: sp|P18100.1|VPR_HV2BE
RefSeq ID: ref|NP_056841.1|
Motifs: PS00005, PS00006, PS00008, PS00001,
Function(s): -Stimulates gene expression driven by the HIV-2 LTR. Prevents infected cells from undergoing mitosis and proliferating, by inducing arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest creates a favourable environment for maximizing viral expression and production.
Description: Stimulates gene expression driven by the HIV-2 LTR. Prevents infected cells from undergoing mitosis and proliferating, by inducing arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest creates a favourable environment for maximizing viral expression and production.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Vpx Gene: vpx Source: HIV2 Acc. No.: PR.H21064042
PDB ID: NA
SwissProt ID: sp|P18099.1|VPX_HV2BE
RefSeq ID: ref|NP_056840.1|
Motifs: PS00005, PS00006, PS00008,
Function(s): -Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. May be necessary for virus replication.
Description: HIV-2 Vpx, a component of the PIC (pre-integration complex), has been shown to be necessary and sufficient for nuclear translocation of the PIC. Determination of the pathway through which Vpx accesses the nucleus may allow for the development of new HIV-inhibitory therapeutics
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References