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Protein Name: nef Gene: nef Source: HIV1 Acc. No.: PR.F38043552
PDB ID: 1QA4
SwissProt ID: sp|P04601.1|
RefSeq ID: ref|NP_057857|
Motifs: PS00006, PS00008, PS00005, PS00001.,
Function(s): -Plays a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Protects the infected cells from apoptosis in order to keep them alive until the next virus generation is ready to strike.
Description: Although HIV-1 Nef was originally named "negative factor," it has been shown to have a positive role in viral replication and pathogenesis. Nef is a viral protein that interacts with host cell signal transduction proteins to provide for long term survival of infected T cells and for destruction of non-infected T cell. Nef also advances the endocytosis and degradation of cell surface proteins, including CD4 and MHC proteins . This action possibly impairs cytotoxic T cell function, thereby helping the virus to evade the host immune response . The multifunctional protein thus helps the virus maintain high viral loads and overcome host immune defenses, contributing to the progression of AIDS.Nef is a 27kD, N-terminal myristoylated accessory protein involved in post integration infection. Nef is found in the viral particle and is one of the first proteins to be detected after invasion of the host cell. Only the structure of core domain has been solved.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Nef Gene: nef Source: HIV2 Acc. No.: PR.C91897139
PDB ID: 3IK5
SwissProt ID: sp|P18092.3|NEF_HV2BE
RefSeq ID: ref|NP_056845.1|
Motifs: PS00006, PS00008, PS00005, PS00001, PS00016, PS00004,
Function(s): -Nef has been shown to be a major determinant of virus pathogenicity,in vivo.But in invitro, many different Nef activities have been reported, including CD4 and MHC I downregulation, enhanced virion infectivity, and T-cell activation.
Description: Nef is a 27 kD myristoylated protein encoded at the 3' ends of the HIV-1, HIV-2, and SIV genomes. It has been shown to play a critical role in the pathogenesis of AIDS in monkeys and therefore is likely to be important for the development of HIV disease in humans.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Nef Gene: nef Source: SIV Acc. No.: PR.K34578461
PDB ID: 3IK5
SwissProt ID: sp|Q02840.3|NEF_SIVG1
RefSeq ID: ref|NP_054373.1|
Motifs: PS00005, PS00006, PS00008, PS00007, PS00009,
Function(s): -To play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Enhances virus infectivity and pathogenicity. Probably involved in viral immune evasion mechanisms.
Description: To play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Enhances virus infectivity and pathogenicity. Probably involved in viral immune evasion mechanisms.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Nef Gene: nef Source: FIV Acc. No.: PR.U44287556
PDB ID: NA
SwissProt ID: sp|P20885.2|REV_FIVPE
RefSeq ID: ref|NP_597786.1|
Motifs: PS00007, PS00006, PS00008,
Function(s): -NA
Description: NA
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References