Home | University of Hyderabad | UOHBIF

 Search result for  'gp120'
Save data in tab delimited text file

Protein Name: Env Gene: env Source: HIV1 Acc. No.: PR.Q81023003
PDB ID: 3JWD
SwissProt ID: sp|P04578.2|ENV_HV1H2
RefSeq ID: ref|NP_057856.1|
Motifs: PS00001, PS00006, PS00008, PS00007, PS00005, PS00009, PS00029,
Function(s): -Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.
Description: Hiv surrounded by the viral envelope that is composed of two layers of fatty molecules called phospholipids taken from the membrane of a human cell when a newly formed virus particle buds from the cell. Embedded in the viral envelope are proteins from the host cell and about 70 copies of a complex HIV protein that protrudes through the surface of the virus particle. External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene.env codes for a protein called gp160 that is broken down by a viral enzyme to form gp120 and gp41. This glycoprotein complex enables the virus to attach to and fuse with target cells to initiate the infectious cycle.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: p7 nucleocapsid Gene: gag Source: HIV1 Acc. No.: PR.E43585406
PDB ID: 1A1T
SwissProt ID: sp|P04591|HIV-1 HXB2 GAG|
RefSeq ID: ref|NP_057849.4|
Motifs: PS50158, PS00008, PS00005,
Function(s): - Encapsulates and protects viral dimeric unspliced (genomic) RNA
- Incorporates viral RNA into virion
- Specific recognition of HIV packaging signal of viral RNA
Description: "The single-stranded RNA is tightly bound to nucleocapsid proteins, p7 and enzymes needed for the development of the virion such as reverse transcriptase, proteases, ribonuclease and integrase.The nucleocapsid (p7 and p6) associates with the genomic RNA (one molecule per hexamer) and protects the RNA from digestion by nucleases. A matrix composed of an association of the viral protein p17 surrounds the capsid, ensuring the integrity of the virion particle. Also enclosed within the virion particle are Vif, Vpr, Nef, p7 and viral protease . The envelope is formed when the capsid buds from the host cell, taking some of the host-cell membrane with it. The envelope includes the glycoproteins gp120 and gp41. "
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Env Gene: env Source: SIV Acc. No.: PR.W51602714
PDB ID: 2BF1
SwissProt ID: sp|Q02837.1|ENV_SIVG1
RefSeq ID: ref|NP_054372.1|
Motifs: PS50325, PS00005, PS00006, PS00008, PS00007, PS00004, PS00001, PS00004,
Function(s): -The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide.
Description: The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References