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Protein Name: Env Gene: env Source: HIV1 Acc. No.: PR.Q81023003
PDB ID: 3JWD
SwissProt ID: sp|P04578.2|ENV_HV1H2
RefSeq ID: ref|NP_057856.1|
Motifs: PS00001, PS00006, PS00008, PS00007, PS00005, PS00009, PS00029,
Function(s): -Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.
Description: Hiv surrounded by the viral envelope that is composed of two layers of fatty molecules called phospholipids taken from the membrane of a human cell when a newly formed virus particle buds from the cell. Embedded in the viral envelope are proteins from the host cell and about 70 copies of a complex HIV protein that protrudes through the surface of the virus particle. External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene.env codes for a protein called gp160 that is broken down by a viral enzyme to form gp120 and gp41. This glycoprotein complex enables the virus to attach to and fuse with target cells to initiate the infectious cycle.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: env Gene: env Source: HIV2 Acc. No.: PR.P35434412
PDB ID: NA
SwissProt ID: sp|P18094|ENV_HV2BE
RefSeq ID: ref|NP_056844.1|
Motifs: PS00006, PS00008, PS00005, PS00001, PS00007, PS00004,
Function(s): -The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.
Description: The genomes of HIV1 and HIV2 are similar there are significant differences in nucleotide and amino acid sequences, most marked with the envelope genes and proteins. Both viruses, however, bind to the same CD4 cellular receptor. HIV2 is largely confined to West Africa where it is the dominant HIV, though patients infected with HIV2 have been described in Europe and America. Its transmission, clinical features and immunological effects are similar to those associated with HIV1 infection.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Env Gene: env Source: SIV Acc. No.: PR.W51602714
PDB ID: 2BF1
SwissProt ID: sp|Q02837.1|ENV_SIVG1
RefSeq ID: ref|NP_054372.1|
Motifs: PS50325, PS00005, PS00006, PS00008, PS00007, PS00004, PS00001, PS00004,
Function(s): -The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide.
Description: The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Env Gene: env Source: FIV Acc. No.: PR.R57345599
PDB ID: NA
SwissProt ID: sp|P16090.2|ENV_FIVPE
RefSeq ID: ref|NP_040976.1|
Motifs: PS50158, PS00006, PS00008, PS00005, PS00001, PS00004,
Function(s): -The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.
Description: The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References


Protein Name: Env Gene: env Source: EIAV Acc. No.: PR.S61785271
PDB ID: NA
SwissProt ID: sp|P11306.2|ENV_EIAV9
RefSeq ID: ref|NP_056903.1
Motifs: PS00006, PS00008, PS00005, PS00001, PS00007, PS00016,
Function(s): -The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.
Description: The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.
Links: Sequence | Structure | MSA1 | MSA2| References | Entrez cross-database search | More..
References