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HIV Integrase

Once Viral RNA is reverse transcribed into double stranded DNA, it should be integrated in to host genome for making further copies. HIV integrase play a key role for theintegration of the viral DNA into the host genome.[Integrase is a key component in the retroviral pre-integration complex(PIC).]HIV Integrase proteins contain three canonical domains, connected by flexible linkers:

Structures of the three domains of HIV-1 integrase shown as ribbon diagrams. A, the catalytic core domain; B,the N-terminal domain;C, the C-terminal domain. Protein Data Bank codes are1BIS,1WJC, and1IHV, respectively.HIV integrase is a 32kDa protein produced from the C-terminal portion of the Pol gene product, and is an attractive target for new anti-HIV drugs.

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  4. Molecular mechanisms of HIV integration and therapeutic intervention Nick Vandegraaff  and Alan Engelman doi: 10.1017/S1462399407000257.

  5. Delelis O, Carayon K, Saib A, Deprez E, Mouscadet J-F: Integrase and integration: biochemical activities of HIV-1 integrase. Retrovirology 2008 , 5:114. PubMed Abstract | BioMed Central Full Text |PubMed Central Full Text

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